UScreen drug test cups and PreScreen Plus cups are two popular 16-panel options for workplace, clinical, rehabilitation, and other screening programs. Both provide fast urine screening and cover substances such as fentanyl, K2, EtG, and tramadol. However, they differ in cutoff levels and cup design. Understanding these differences can help you select the right 16-panel drug test for your testing needs.
Quick Answer: The UScreen drug test and PreScreen Plus Mega Cup have very similar 16-panel configurations. The primary panel difference is the opiate cutoff: UScreen tests for MOP300, while the PreScreen Mega Cup tests for OPI2000.
In This Guide
- UScreen Drug Test vs. PreScreen Plus: Quick Comparison
- What Does the UScreen 16-Panel Drug Test Test For?
- How Do UScreen and PreScreen Plus Drug Panels Compare?
- How Do UScreen and PreScreen Plus Cup Features Compare?
- UScreen or PreScreen Plus: Which 16-Panel Cup Should You Choose?
UScreen Drug Test vs. PreScreen Plus: Quick Comparison
| Feature / Specification | UScreen Plus 16-Panel Cup | PreScreen Plus 16-Panel Mega Cup |
| Sample Type | Urine | Urine |
| Panel Count | 16 substances | 16 substances |
| Common Drugs Tested | Fentanyl, K2, EtG, tramadol, opioids | Fentanyl, K2, EtG, tramadol, opioids |
| Cup Shape / Design | 4-sided square shape for easy reading | Standard round multi-panel mega cup |
| Result Speed | Results within 5 minutes | Results within 5 Minutes |
| Result Stability | Stable up to 60 minutes | Stable up to 60 minutes |
| Primary Intended Use | Forensic Use Only (FUO) | Forensic Use Only (FUO) |
What Does the UScreen 16-Panel Drug Test Test For?
The UScreen 16-panel drug test by Trans Med Company is a urine screening cup that detects 16 drug classes and metabolites in a single test. Its panel includes several commonly screened substances along with fentanyl, EtG (an alcohol metabolite), synthetic cannabinoids (K2), oxycodone, and tramadol.
The UScreen Plus tests for:
- Amphetamines (AMP)
- Barbiturates (BAR)
- Buprenorphine (BUP)
- Benzodiazepines (BZO)
- Cocaine (COC)
- EtG (ethyl glucuronide)
- Fentanyl (FEN)
- K2 / synthetic cannabinoids
- Methamphetamine (mAMP)
- MDMA
- Methadone (MTD)
- Morphine/Opiates (MOP)
- Oxycodone (OXY)
- PCP
- THC
- Tramadol (TRA)
The specific UScreen cup being compared here uses a MOP300 cutoff for its opiate panel. This is one of the main differences between UScreen Plus and the PreScreen Plus Mega Cup, which uses an OPI2000 cutoff. We’ll compare the complete cutoff configurations below.
How Do You Read UScreen Drug Test Cup Results?
You can read UScreen drug test cup results directly from the test strips after specimen collection and the required waiting period.
- Collect the urine specimen and close the cup securely.
- Check the built-in temperature strip, which should read 90°F to 100°F.
- Peel back the label to expose the test strips.
- Read negative results at approximately 90 seconds.
- Allow up to 5 minutes to confirm presumptive positive results.
- Two lines indicate a negative result, while only the control line indicates a presumptive positive result. A faint second line is also considered negative.
Always follow the instructions in the UScreen drug test cup package insert supplied with the specific product.
How Do UScreen and PreScreen Plus Drug Panels Compare?
The UScreen and PreScreen Plus are closely matched 16-panel urine drug tests. They screen for the same 16 drug classes and metabolites, and 15 of their 16 listed cutoff levels match. The primary difference is the opiate panel: UScreen uses a MOP300 cutoff, while PreScreen Plus uses OPI2000.
| Drug / Analyte | UScreen Plus Cutoff | PreScreen Plus Cutoff |
| Amphetamines (AMP) | 1,000 ng/mL | 1,000 ng/mL |
| Barbiturates (BAR) | 300 ng/mL | 300 ng/mL |
| Buprenorphine (BUP) | 10 ng/mL | 10 ng/mL |
| Benzodiazepines (BZO) | 300 ng/mL | 300 ng/mL |
| Cocaine (COC) | 300 ng/mL | 300 ng/mL |
| EtG | 500 ng/mL | 500 ng/mL |
| Fentanyl (FEN) | 10 ng/mL | 10 ng/mL |
| K2 / Synthetic Cannabinoids | 50 ng/mL | 50 ng/mL |
| Methamphetamine (MET/mAMP) | 1,000 ng/mL | 1,000 ng/mL |
| MDMA | 500 ng/mL | 500 ng/mL |
| Methadone (MTD) | 300 ng/mL | 300 ng/mL |
| Opiates (MOP/OPI) | MOP 300 ng/mL | OPI 2,000 ng/mL |
| Oxycodone (OXY) | 100 ng/mL | 100 ng/mL |
| PCP | 25 ng/mL | 25 ng/mL |
| THC | 50 ng/mL | 50 ng/mL |
| Tramadol (TRA) | 200 ng/mL | 200 ng/mL |
From a panel-coverage standpoint, neither cup offers more drug classes than the other in these specific configurations. Instead, the key consideration is the different opiate cutoff, which can affect when an opiate screening result becomes reactive.
What Is the Difference Between MOP300 and OPI2000?
The main difference between the two products is the opiate cutoff level. The UScreen drug test uses MOP300, while the PreScreen Plus Mega Cup uses OPI2000.
- MOP300: Uses a 300 ng/mL cutoff, allowing the test to detect lower concentrations of opiates. Lower cutoffs may also be more sensitive to concentrations associated with some prescription use or dietary exposure, which can potentially lead to a false-positive drug test from substances like poppy seeds.
- OPI2000: Uses a 2,000 ng/mL cutoff. This threshold aligns with federal screening standards set by SAMHSA to intentionally rule out accidental dietary exposure and focus instead on heavier misuse or illicit abuse.
For buyers, the cutoff level can be more important than the panel count. The better option depends on the testing program’s requirements and the desired screening threshold. DrugTestsInBulk (DTIB) offers the PreScreen Plus Mega Cup for organizations seeking a 16-panel screening option with an OPI2000 cutoff.
Sixteen Panel PreScreen Plus Mega Cup (FUO)
Great for rehab and no tolerance testing
How Do UScreen and PreScreen Plus Cup Features Compare?
The best drug test cups fit your testing workflow. Features such as cup design, lid and seal, temperature verification, specimen validity and adulteration checks, and ease of reading can influence the right choice.
Both cups perform similarly on most core features:
- Result Time: Results within 5 minutes for both cups
- Temperature Verification: Both urine drug test cups include a built-in temperature strip for checking the specimen after collection
- Panel Coverage: Both offer comparable expanded screening, including fentanyl, K2, EtG, and tramadol
- Result Stability: Both remain stable for up to 60 minutes after the reading period
- Handling: Both are self-contained cups that activate without tipping or transferring the specimen
The real differences come down to:
- Cup Design: UScreen uses a four-sided square cup with a click-seal cap; PreScreen Plus Mega Cup uses a traditional round, multi-panel design
- Cutoff Level: UScreen uses a MOP300 opiate cutoff; PreScreen Plus uses OPI2000
UScreen or PreScreen Plus: Which 16-Panel Cup Should You Choose?
Both UScreen and PreScreen Plus deliver reliable 16-panel urine screening, so the right pick comes down to your specific cutoff requirements, order volume, and workflow preferences.
UScreen may make more sense if:
- You prefer a MOP300 opiate cutoff, which can detect lower concentrations of opiates.
- A four-sided square cup design fits your reading and handling workflow.
- You’re ordering smaller quantities. UScreen is listed at $165.25 for 25 cups, or approximately $6.61 per test.
PreScreen Plus may make more sense if:
- You prefer an OPI2000 opiate cutoff, which aligns with SAMHSA federal screening standards and is designed to reduce positives from incidental exposure.
- A traditional round mega cup design fits your workflow.
- You’re buying in larger quantities. PreScreen Plus is listed at $214.75 for 25 cups, or approximately $8.59 per test, but drops to $64.75 per 25-cup case, or approximately $2.59 per test, at 275+ cups.
For organizations purchasing drug tests in larger quantities, DrugTestsInBulk (DTIB) offers urine and saliva drug test options under its PreScreen Plus brand along with a broader selection of bulk drug testing supplies, making it easier to choose products based on testing needs and order volume.
Neither product is automatically better for every testing program. The right choice depends on your required cutoff level, intended use, testing workflow, and order quantity.
FAQs About UScreen Drug Tests
How long does a UScreen drug test take?
The UScreen drug test cup delivers negative results in 60- 90 seconds and presumptive positive results within 5 minutes.
Does the UScreen 16-panel drug test detect fentanyl?
Yes. The UScreen Plus 16-panel cup includes FEN10, which is the fentanyl screening panel.
Is the UScreen 16-Panel Drug Test CLIA-waived?
Yes, UScreen Cup is designated for forensic or workplace use rather than being marketed as CLIA-waived for point-of-care clinical diagnostics.
