John William Huffman (born 1932) is a professor emeritus of organic chemistry at Clemson University who first synthesised many novel cannabinoids. His research, funded by the National Institute on Drug Abuse, was focused on making a drug to target endocannabinoid receptors in the body. Beginning in 1984, Huffman and his team of researchers began developing cannabinoid compounds to aid in research of multiple sclerosis, AIDS, and chemotherapy.